A Civatte body (named after the French dermatologist Achille Civatte, 1877–1956) is a damaged basal keratinocyte that has undergone apoptosis, and consist largely of keratin intermediate filaments, and are almost invariably covered with immunoglobulins, mainly IgM.

Civatte bodies HP:0025115 Eosinophilic hyaline ovoid bodies which are often found in the subepidermal papillary regions or sometimes in the epidermis. Civatte bodies (CBs) are seen as rounded, homogenous, eosinophilic masses on routine H and E staining lying in the deeper parts of epidermis/epithelium and more frequently in dermis/connective tissue.

Medical Definition of Civatte bodies. 1. Eosinophilic hyaline spherical body's seen in or just beneath the epidermis, particularly in lichen planus, formed by necrosis of individual basal cells. Synonym: colloid bodies. (05 Mar 2000) Lexicographical Neighbors of Civatte Bodies Civatte Bodies [2] These might be referred as colloid Bodies. However, some references refer to colloid Bodies as apoptotic cell remnants in papillary dermis, whereas Civatte bodies as apoptotic cell remnants in epidermis.

Civatte bodies

Jun 13, 2019 This epidermal basal cell damage can be of two forms: vacuolar/hydropic degeneration and filamentous degeneration (resulting in Civatte bodies) Lupus is a chronic autoimmune condition that can cause inflammation throughout your body. However, it tends to primarily be a localized condition, so it's not Isolated, degenerated keratinocytes (Civatte, or hyaline, bodies) are present at the epithelial-stromal junction (figures 2 and 3). Erosive LP may show ulceration or Jun 12, 2018 were observed along with a focal lichenoid inflammatory cell infiltrate with colloid bodies corresponding to Civatte bodies. At the dermal level, and civatte bodies near the tips of rete ridges, consistent with hypertrophic lichen planus (Figure 3). He was treated with topical clobetasol ointment twice daily Close. Indian J Med Microbiol. Figure 2: (a) Photomicrograph of classic lichen planus, (H and E, ×100).

The presence of numerous civatte bodies (CBs) in biopsies is a characteristic finding in skin lesions of patients with various dermatoses, particularly lichen planus (LP) and discoid lupus erythematosus (DLE). In the absence of a clear diagnosis, their presence is suggestive of disorders characterized by interface dermatitis.

COMMENT: The histologic sections show squamous mucosa with increased intraepithelial lymphocytes with a prominent lichenoid pattern of injury with numerous apoptotic keratinocytes (“Civatte bodies”). This pattern of injury is nonspecific and can be seen in association with gastroesophageal reflux (GERD), cutaneous lichen planus, contact mucositis, graft-versus-host disease, certain medications (including NSAIDs, among many others), viral infections, Crohn’s disease, and pill esophagitis.

Civatte bodies . Wedge-shaped hypergranulosis “Saw-tooth” rete ridges .

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Se hela listan på hindawi.com Focal hypergranulosis and focal parakeratosis is present. Numerous Civatte bodies are identified. The focal hypergranulosis is not wedge-shaped. There are no pointed rete ridges. There is no basal squamatization.
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Also called colloid bodies, they are formed by necrosis of individual basal cells Clarke bodies - Intranuclear bodies found in alveolar breast sarcoma (see image below). Within the stratum basale there is occasional hydropic degeneration and apoptosis (Civatte bodies), and basal keratinocytes are often disorganized or jumbled. Within the superficial dermis, scattered macrophages contain melanin (pigmentary incontinence).

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Who Described Civatte Bodies? Who Described Civatte Bodies? Burgdorf, Walter H. C.; Plewig, Gerd 2014-04-01 00:00:00 Eosinophilic apoptotic (necrotic) keratinocytes in the lower epidermis and at the dermoepidermal junction are a feature of many interface dermatoses but are most reliably found in lichen planus.

Within the superficial dermis, scattered macrophages contain melanin (pigmentary incontinence). There is mild, diffuse apocrine gland ectasia and lymphatics are ectatic (edema).

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keratinocytes (Civatte, or hyaline, bodies) are present at the epithelial-stromal junction (figures 2 and 3). Erosive LP may show ulceration or a sub-basal separa-tion of the epithelium from the stroma.